James Hamilton, 2nd Earl of Clanbrassil, KG, KP, PC (I) (23 August 1730 – 6 February 1798), was an Anglo-Irish peer, styled Viscount Limerick from 1756 to 1758. Lord Clanbrassil was the son of James Hamilton, 1st Earl of Clanbrassil, and Lady Harriet Bentinck. The Hamilton dynasty were an Ulster-Scots family by origin. He married The Hon. Grace Foley, daughter of The 1st Baron Foley and The Hon. Grace Granville, on 21 May 1774 at Oxford Chapel, Marylebone. He died without issue in 1798 and his titles became extinct. His name survives in that of Clanbrassil Street, Dublin.