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A calpain (/ˈkælpeɪn/; EC 3.4.22.52, EC 3.4.22.53) is a protein belonging to the family of calcium-dependent, non-lysosomal cysteine proteases (proteolytic enzymes) expressed ubiquitously in mammals and many other organisms. Calpains constitute the C2 family of protease clan CA in the MEROPS database. The calpain proteolytic system includes the calpain proteases, the small regulatory subunit CAPNS1, also known as CAPN4, and the endogenous calpain-specific inhibitor, calpastatin.

AttributesValues
rdf:type
rdfs:label
  • Calpain (en)
  • Calpaína (es)
  • Calpaïne (fr)
  • カルパイン (ja)
  • Calpaína (pt)
  • 钙蛋白酶 (zh)
rdfs:comment
  • A calpain (/ˈkælpeɪn/; EC 3.4.22.52, EC 3.4.22.53) is a protein belonging to the family of calcium-dependent, non-lysosomal cysteine proteases (proteolytic enzymes) expressed ubiquitously in mammals and many other organisms. Calpains constitute the C2 family of protease clan CA in the MEROPS database. The calpain proteolytic system includes the calpain proteases, the small regulatory subunit CAPNS1, also known as CAPN4, and the endogenous calpain-specific inhibitor, calpastatin. (en)
  • Las calpaínas (EC 3.4.22.52, EC 3.4.22.53) son , no lisosomales, cuya actividad, de tipo papaína, es dependiente de calcio. Estas enzimas son responsables de la proteólisis neutra calcio-dependiente, en virtud de un dominio de unión a calcio. Este dominio se denomina calmodulin-like por ser altamente homólogo a la calmodulina, presentando las estructuras típicas manos EF de unión a ion calcio. El centro activo de las calpaínas está compuesto de una tríada catalítica formada por cisteína (C), histidina (H) y Asparagina (N). (es)
  • Les calpaïnes (EC 3.4.22.52, EC 3.4.22.53) sont des protéases à cystéine, non-lysosomiales, dont l'activité, de type papaïne, est dépendante du calcium. Ces enzymes sont responsables de la protéolyse neutre calcium-dépendante. Les calpaïnes possèdent un domaine leur permettant d'interagir avec le calcium. Ce domaine, fortement homologue à la calmoduline, est dit calmodulin-like et présente des structures EF-Hand capables de lier les ions calcium. Le site actif des calpaïnes est constitué de trois acides aminés (triade catalytique): Cystéine (C), Histidine (H) et Asparagine (N). (fr)
  • カルパイン（calpain, EC 3.4.22.52, EC 3.4.22.53）は、カルシウム依存的非リソソームシステインプロテアーゼファミリーに属するタンパク質である。哺乳類や他の多くの生物種で普遍的に発現している。カルパインはMEROPSデータベースにおいてclan CAのfamily C2を構成する。カルパインのタンパク質分解システムはカルパインプロテアーゼ、調節サブユニット (CAPN4)、そして内在性のカルパイン特異的阻害因子であるによって構成される。 (ja)
  • 钙蛋白酶（EC 3.4.22.52, EC 3.4.22.53）是一种蛋白质，属于钙依赖性、非溶酶体半胱氨酸蛋白酶（蛋白水解酶）家族，在哺乳动物和许多其他生物体中普遍表达。钙蛋白酶构成MEROPS数据库中蛋白酶族CA的C2家族。钙蛋白酶蛋白水解系统包括钙蛋白酶、小的调节亚基（也称为CAPN4）和内源性钙蛋白酶特异性抑制剂，。 (zh)
  • As calpaínas representam uma família bem conservada de proteases de cisteína dependentes de cálcio. A atividade da calpaína in vivo é altamente regulada pelas (calpastatin), as calpastatinas inibem especificamente as calpaínas, não inibindo outras proteases de cisteína, através de suas interações com vários sítios das calpaínas. A má regulação das calpaínas pelas calpastatinas está associada a várias desordens patológicas humanas, incluindo distrofia muscular, câncer, doença de Alzheimer, injuria neurológica, diabetes e formação de catarata. Pesquisas recentes estão elucidando as estruturas primárias das calpaína 2 e do domínio regulatório calpaína 4, junto com a descoberta de novos meios de se regular a atividade das calpaínas providenciam novas oportunidades de se desenvolver novos tipo (pt)
name
  • Calpain (en)
  • calpain-1 (en)
  • calpain-2 (en)
foaf:depiction
  • http://commons.wikimedia.org/wiki/Special:FilePath/PDB_1mdw_EBI.jpg
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