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Samuel David Gross (July 8, 1805 – May 6, 1884) was an American academic trauma surgeon. Surgeon biographer Isaac Minis Hays called Gross "The Nestor of American Surgery." He is immortalized in Thomas Eakins' The Gross Clinic (1875), a prominent American painting of the nineteenth century. A bronze statue of him was cast by Alexander Stirling Calder and erected on the National Mall, but moved in 1970 to Thomas Jefferson University in Philadelphia.

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