Laura Mancini (6 May 1636 – 8 February 1657) was a niece of Cardinal Mazarin. She was the eldest of the five famous Mancini sisters, who along with two of their female Martinozzi cousins, were known at the court of Louis XIV of France as the Mazarinettes. She married Louis de Bourbon, Duke of Vendôme, grandson of King Henry IV and was the mother of the great general the Duke of Vendôme.