State Route 169 (SR 169) is a state highway in the U.S. state of California that is separated into two distinct segments by undeveloped areas in the Yurok Indian Reservation in Del Norte and Humboldt counties. The western segment runs from U.S. Route 101 near Klamath to Klamath Glen, while the eastern segment goes from Wautec Village to State Route 96 near Weitchpec.