The 2021–22 season is Stevenage's eighth consecutive season in League Two and their 46th year in existence. Along with competing in League Two, the club are also participating in the FA Cup, the EFL Cup and the EFL Trophy. The season covers the period from 1 July 2021 to 30 June 2022. Manager Alex Revell left the club on 15 November 2021 with the club having won three of their opening 16 league matches. Academy manager Robbie O’Keefe was named as caretaker manager while the club looked for a replacement. Paul Tisdale was appointed as manager on 28 November 2021. Stevenage and Tisdale parted ways on March 16, 2022, with Steve Evans taking charge as manager.