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Quinagolide (INN, BAN), sold under the brand name Norprolac, is a selective dopamine D2 receptor agonist which is used to reduce elevated levels of prolactin (hyperprolactinemia). It has also been found to be effective in the treatment of breast pain.

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rdf:type
rdfs:label
  • Quinagolid (de)
  • Quinagolide (it)
  • Norprolac (nl)
  • Quinagolide (en)
  • Chinagolid (pl)
rdfs:comment
  • Quinagolid ist ein synthetisch hergestelltes Gemisch zweier chemischer Verbindungen aus den Gruppen der Decahydrochinolin-Derivate und der Sulfonsäureamide. Der Arzneistoff aus der Gruppe der Dopaminagonisten mit nicht-ergoliner Struktur hemmt die Ausschüttung (Sekretion) des Hormons Prolaktin und wird deswegen zur Behandlung krankhaft erhöhter Prolaktinspiegel im Blut (Hyperprolaktinämie) eingesetzt. Quinagolid wurde bei Sandoz entwickelt und 1983 zum Patent angemeldet. Meist wird statt der freien Base das besser wasserlösliche Hydrochlorid eingesetzt. (de)
  • Quinagolide (INN, BAN), sold under the brand name Norprolac, is a selective dopamine D2 receptor agonist which is used to reduce elevated levels of prolactin (hyperprolactinemia). It has also been found to be effective in the treatment of breast pain. (en)
  • Quinagolide (nella fase sperimentale conosciuta anche con la sigla CV 205-502) è una molecola ergotaminica non derivata dalla segale cornuta, che agisce come un agonista selettivo del recettore D2 della dopamina e trova impiego nel trattamento di soggetti che presentano alti livelli di prolattina. (it)
  • Chinagolid, łac. Quinagolidum – organiczny związek chemiczny, selektywny agonista receptorów D2 dopaminy. Hamuje uwalnianie prolaktyny z przysadki mózgowej. Szybko wchłania się z przewodu pokarmowego. Biologiczny okres półtrwania wynosi 11,5–17 godzin. (pl)
  • Norprolac is een middel om een te hoge prolactine-waarde te verminderen. De werkzame stof in Norprolac is . Quinagolide werkt hetzelfde als dopamine, een stof die van nature in de hersenen voorkomt. Quinagolide onderdrukt de aanmaak van prolactine.Behalve het gewenste effect kan dit middel bijwerkingen als 'maag-darmklachten', 'hart-vaatklachten', en 'psychischebijwerkingen' hebben. (nl)
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  • http://commons.wikimedia.org/wiki/Special:FilePath/(+)-Quinagolid_Structural_Formula_V1.svg
  • http://commons.wikimedia.org/wiki/Special:FilePath/(+-)-Quinagolid_Structural_Formula_V1.svg
  • http://commons.wikimedia.org/wiki/Special:FilePath/(-)-Quinagolid_Structural_Formula_V1.svg
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ATC suffix
  • CB04 (en)
ATC prefix
  • G02 (en)
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CAS number
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IUPAC name
  • N,N-diethyl-N-[-6-hydroxy-1-propyl-1,2,3,4,4a,5,10,10a-octahydrobenzo[g]quinolin-3-yl]sulfamide (en)
KEGG
  • D07217 (en)
legal status
  • Rx-only (en)
n
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PubChem
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