Panagiotis Spiliotopoulos (Greek: Παναγιώτης Σπηλιωτόπουλος, 1891–1962) was a Hellenic Army officer who rose to the rank of Lieutenant General and held the post of Chief of the Hellenic Army General Staff in 1946–1947, during the first stages of the Greek Civil War. He also served briefly as Minister of National Defence, Minister for Northern Greece and Secretary General of the Hellenic Red Cross.