Murrough Ó Laoí (fl. 1668 – 1684) was an Irish physician. Ó Laoí was a descendant of a hereditary medical family to the O'Flahertys, who were first mentioned in Crichaireacht cinedach nduchasa Muintiri Murchada, c. 1000. They moved west across Lough Corrib with the O'Flahertys, continuing their profession into the 17th century. Ó Laoí lived in Letterdeskert, just west of Carna, County Galway.