About: History of molecular evolution

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The history of molecular evolution starts in the early 20th century with "comparative biochemistry", but the field of molecular evolution came into its own in the 1960s and 1970s, following the rise of molecular biology. The advent of protein sequencing allowed molecular biologists to create phylogenies based on sequence comparison, and to use the differences between homologous sequences as a molecular clock to estimate the time since the last common ancestor. In the late 1960s, the neutral theory of molecular evolution provided a theoretical basis for the molecular clock, though both the clock and the neutral theory were controversial, since most evolutionary biologists held strongly to panselectionism, with natural selection as the only important cause of evolutionary change. After the 1

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rdfs:label	History of molecular evolution (en) 분자 진화사 (ko) História da evolução molecular (pt)
rdfs:comment	분자 진화사는 20세기 초 비교생화학과 함께 시작되지만 분자 진화 분야는 1960년대와 1970년대 분자생물학의 등장에 따라 독자적으로 등장했다. 단백질 시퀀싱의 출현으로 분자 생물학자들은 서열 비교를 기반으로 계통 발생을 만들고 상동 서열 간의 차이를 분자 시계로 사용하여 마지막 공통 조상 이후의 시간을 추정할 수 있게 되었다. 1960년대 후반, 중립 진화 이론은 분자 시계의 이론적 기초를 제공했지만 시계와 중성 이론 모두 논쟁의 여지가 있다. 대부분의 진화 생물학자들이 진화론적 진화의 유일한 중요한 원인으로서 범선택론을 강력하게 지지했기 때문이다. 1970년대 이후, 핵산 염기서열 분석은 분자 진화가 단백질을 넘어 고도로 보존된 리보솜 RNA 염기서열까지 도달하도록 허용했으며, 이는 초기 생명 역사에 대한 재개념화의 기초가 되었다. (ko) The history of molecular evolution starts in the early 20th century with "comparative biochemistry", but the field of molecular evolution came into its own in the 1960s and 1970s, following the rise of molecular biology. The advent of protein sequencing allowed molecular biologists to create phylogenies based on sequence comparison, and to use the differences between homologous sequences as a molecular clock to estimate the time since the last common ancestor. In the late 1960s, the neutral theory of molecular evolution provided a theoretical basis for the molecular clock, though both the clock and the neutral theory were controversial, since most evolutionary biologists held strongly to panselectionism, with natural selection as the only important cause of evolutionary change. After the 1 (en) A história da evolução molecular começa no início do século XX com a "bioquímica comparada", mas o campo da evolução molecular só se tornou independente durante as décadas de 1960 e 70, seguindo o aparecimento da biologia molecular. O advento da sequenciação de proteínas permitiu que biólogos moleculares criassem comparação de proteínas à base de filogenias, e de usar as diferenças entre sequências homólogas como um relógio molecular para estimar o tempo decorrido desde o último ancestral comum. No fim da década de 60, a teoria neutral da evolução molecular forneceu a base teórica para o relógio molecular, embora tanto o relógio como a teoria neutral fossem controversas, uma vez que a maioria dos biólogos evolutivos se mantivessem fieis ao , com a selecção natural como a única causa import (pt)
dcterms:subject	History of biology by subdiscipline Molecular evolution
Wikipage page ID	11863361 (xsd:integer)
Wikipage revision ID	1098751321 (xsd:integer)
Link from a Wikipage to another Wikipage	Carl Woese Primate Electrophoresis Morris Goodman Methanogen Non-Darwinian evolution Belgium History of life Richard Lewontin Cytochrome c Infinite alleles model J. C. King Rutgers University Gene-centered view of evolution Generation time Genetic divergence Genetic load George Fox Natural selection Neutral theory of molecular evolution Emanuel Margoliash Emil L. Smith Emile Zuckerkandl Frederick Sanger George C. Williams (biologist) Modern synthesis (20th century) Molecular clock Morphology (biology) Motoo Kimura Theodosius Dobzhansky Thomas H. Jukes Archaea Linus Pauling History of biology by subdiscipline Haldane's dilemma Marcel Florkin Bacteria Bruce Wallace (geneticist) Bruges Adaptation and Natural Selection Adaptive radiation Tomoko Ohta Walter Gilbert Adaptationism Alfred Sturtevant Molecular evolution DNA sequencing Darwinian Ernest Baldwin Ernst Mayr Animal Fixation (population genetics) Francis Crick Base pair Nothing in biology makes sense except in the light of evolution Panselectionism Paper chromatography Cell biology Charles Sibley Endosymbiotic Journal of Molecular Evolution HGB J. B. S. Haldane James F. Crow George Nuttall Heterosis Heterozygote advantage Assay Group selection DNA hybridization Dobzhansky H. J. Muller Insulin Organelle Cartesianism Proximate causation Nearly neutral theory of molecular evolution Digestive enzymes Noncoding DNA Protein sequencing Molecular biology Walter Schroeder Molecular evolution Overdominance RNA world Ribosomal RNA Three-domain system Units of selection Archaebacteria Origin of life

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