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About: GlmS glucosamine-6-phosphate activated ribozyme     Goto   Sponge   NotDistinct   Permalink

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Type: yago:WikicatCis-regulatoryRNAElementsyago:Abstraction100002137yago:Cognition100023271yago:Component105868954yago:Concept105835747yago:Content105809192yago:Idea105833840yago:Part105867413yago:PsychologicalFeature100023100building New Facet based on Instances of this Class

The glucosamine-6-phosphate riboswitch ribozyme ( glmS ribozyme) is an RNA structure that resides in the 5' untranslated region (UTR) of the mRNA transcript of the glmS gene. This RNA regulates the glmS gene by responding to concentrations of a specific metabolite, glucosamine-6-phosphate (GlcN6P), in addition to catalyzing a self-cleaving chemical reaction upon activation. This cleavage leads to the degradation of the mRNA that contains the ribozyme, and lowers production of GlcN6P. The glmS gene encodes for an enzyme glutamine-fructose-6-phosphate amidotransferase, which catalyzes the formation of GlcN6P, a compound essential for cell wall biosynthesis, from fructose-6-phosphate and glutamine. Thus, when GlcN6P levels are high, the glmS ribozyme is activated and the mRNA transcript is de