About: Gary Ruvkun

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Gary Bruce Ruvkun (born March 1952, Berkeley, California) is an American molecular biologist at Massachusetts General Hospital and professor of genetics at Harvard Medical School in Boston. Ruvkun discovered the mechanism by which lin-4, the first microRNA (miRNA) discovered by Victor Ambros, regulates the translation of target messenger RNAs via imperfect base-pairing to those targets, and discovered the second miRNA, let-7, and that it is conserved across animal phylogeny, including in humans. These miRNA discoveries revealed a new world of RNA regulation at an unprecedented small size scale, and the mechanism of that regulation. Ruvkun also discovered many features of insulin-like signaling in the regulation of aging and metabolism.He was elected a Member of the American Philosophical S

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rdfs:label	غاري روفكون (ar) Gary Ruvkun (de) Gary Ruvkun (es) Gary Ruvkun (en) Равкан, Гэри (ru) Gary Ruvkun (pt) 加里·鲁夫昆 (zh)
rdfs:comment	غاري بروس روفكون (بالإنجليزية: Gary Ruvkun)‏ (من مواليد 26 مارس 1952، بيركلي، كاليفورنيا) هو عالم الأحياء الجزيئي الأمريكي في مستشفى ماساتشوستس العام وأستاذ علم الوراثة في كلية الطب بجامعة هارفارد في بوسطن. اكتشف روفكون الآلية التي من خلالها يقوم lin-4، أول حمض ريبوزي نووي ميكروي (miRNA) الذي اكتشفه فيكتور إمبروس، بتنظيم ترجمة الحمض النووي الريبي للمراسلات المستهدفة عبر الإقران الأساسي الناقص لتلك الأهداف، واكتشاف (miRNA) الثاني، let-7، وأنه يتم حفظها عبر نسالة الحيوانات، بما في ذلك في البشر. كشفت هذه الاكتشافات (miRNA) عالم جديد من تنظيم الحمض النووي الريبي في حجم صغير لم يسبق له مثيل، وآلية هذا التنظيم. اكتشف روفكون أيضًا العديد من ميزات الإشارات التي تشبه الأنسولين في تنظيم الشيخوخة والتمثيل الغذائي. انتخب عضوا في الجمعية الفلسفية الأمريكية في عام 2019. (ar) Gary Ruvkun es un biólogo molecular estadounidense y profesor de genética de la Harvard Medical School en Boston. Sus descubrimientos relativos a Micro ARN le valieron el Premio Lasker por Investigación Médica Básica en 2012, junto a Victor Ambros y David Baulcombe. (es) Gary Bruce Ruvkun (Berkeley, Califórnia, 26 de março de 1952) é um biólogo molecular estadunidense. Trabalha no Massachusetts General Hospital e é professor de genética da Harvard Medical School em Boston. (pt) 加里·布魯斯·鲁夫昆（英語：Gary Bruce Ruvkun，1952年3月26日－），美国分子生物学家，波士顿哈佛医学院遗传学教授。1973年在伯克利加州大学获学士学位，后在哈佛大学获博士学位。Ruvkun发现了首例微RNA——lin-4通过与目标信使RNA不完全碱基配对来调控这些目标的翻译的机制，并发现了第二个微RNA——，以及它在动物（包括人类）系统发育中如何保护的。 (zh) Gary Bruce Ruvkun (* 26. März 1952 in Berkeley, Kalifornien) ist ein US-amerikanischer Genetiker und Professor an der Harvard University. Ruvkun erwarb 1973 einen Bachelor in Biophysik an der University of California, Berkeley und 1982 bei einen Ph.D. in Biophysik an der Harvard University. Stellen als Postdoktorand hatte er bei H. Robert Horvitz am Massachusetts Institute of Technology (gemeinsam mit Victor Ambros) und bei Walter Gilbert an der Harvard University. Seit 1985 hat er eine Professur für Genetik an der Harvard Medical School, zunächst als Assistant Professor, dann als Associate Professor und zuletzt als ordentlicher Professor. (de) Gary Bruce Ruvkun (born March 1952, Berkeley, California) is an American molecular biologist at Massachusetts General Hospital and professor of genetics at Harvard Medical School in Boston. Ruvkun discovered the mechanism by which lin-4, the first microRNA (miRNA) discovered by Victor Ambros, regulates the translation of target messenger RNAs via imperfect base-pairing to those targets, and discovered the second miRNA, let-7, and that it is conserved across animal phylogeny, including in humans. These miRNA discoveries revealed a new world of RNA regulation at an unprecedented small size scale, and the mechanism of that regulation. Ruvkun also discovered many features of insulin-like signaling in the regulation of aging and metabolism.He was elected a Member of the American Philosophical S (en) Гэри Равкан (англ. Gary Ruvkun; род. 26 марта 1952, Беркли, штат Калифорния) — американский учёный. Труды в основном посвящены молекулярной биологии и генетике. Член Национальных Академии наук (2008) и (2009) США, а также Американского философского общества (2019). Лауреат многих престижных премий. (ru)
dcterms:subject	1952 births Living people American geneticists Harvard Medical School alumni Harvard Medical School faculty Jewish American scientists Members of the American Philosophical Society Members of the National Academy of Medicine Members of the United States National Academy of Sciences Recipients of the Albert Lasker Award for Basic Medical Research University of California, Berkeley alumni Massry Prize recipients 21st-century American Jews Biogerontologists
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Link from a Wikipage to another Wikipage	Caenorhabditis elegans MicroRNA Keck School of Medicine C. David Allis Berkeley, California Boston Brandeis University Breakthrough Prize in Life Sciences David Baulcombe DNA sequencer United States University of California, Berkeley University of Southern California Victor Ambros Earliest known life forms Life on Mars Gairdner Foundation International Award 1952 births Living people Columbia University Craig Mello Massachusetts General Hospital Massachusetts Institute of Technology Genetics Frederick M. Ausubel NASA Andrew Fire Life March of Dimes Prize in Developmental Biology Massry Prize American geneticists Harvard Medical School alumni Harvard Medical School faculty Jewish American scientists Members of the American Philosophical Society Members of the National Academy of Medicine Members of the United States National Academy of Sciences Recipients of the Albert Lasker Award for Basic Medical Research University of California, Berkeley alumni Massry Prize recipients Walter Gilbert Dr. Paul Janssen Award for Biomedical Research Panspermia American Philosophical Society 21st-century American Jews Cynthia Kenyon Dan David Prize Cell (journal) Nitrogen fixation

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