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About: Bombesin     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : umbel-rc:ChemicalSubstanceType, within Data Space : dbpedia.org associated with source document(s)

Type: Thingdul:ChemicalObjectchemical substanceChemical compoundyago:WikicatNeurotransmittersyago:Abstraction100002137yago:Amide114724264yago:Base114618253yago:Chemical114806838yago:Compound114818238yago:Imidazole114916670yago:Macromolecule114944888yago:Material114580897yago:Matter100020827yago:Molecule114682133yago:Neurochemical114807410yago:Neurotransmitter114807558yago:OrganicCompound114727670yago:Part113809207yago:Peptide114743046yago:PhysicalEntity100001930yago:Protein114728724yago:Relation100031921yago:WikicatImidazoleschemical compoundyago:Substance100019613yago:Thing100002452yago:Unit109465459yago:WikicatPeptidesyago:WikicatProteinsumbel-rc:ChemicalSubstanceType New Facet based on Instances of this Class

Bombesin is a 14-amino acid peptide originally isolated from the skin of the European fire-bellied toad (Bombina bombina) by Vittorio Erspamer et al. and named after its source. It has two known homologs in mammals called neuromedin B and gastrin-releasing peptide. It stimulates gastrin release from G cells. It activates three different G-protein-coupled receptors known as BBR1, -2, and -3. It also activates these receptors in the brain. Together with cholecystokinin, it is the second major source of negative feedback signals that stop eating behaviour.