About: BRCA mutation

Facets (new session)
Description
Metadata
Settings
- Rule:
- Inverse Functional Properties:
- "Same As":

About: BRCA mutation Goto Sponge NotDistinct Permalink

An Entity of Type : yago:Tumor114235200, within Data Space : dbpedia.org associated with source document(s)
QRcode icon

http://dbpedia.org/describe/?url=http%3A%2F%2Fdbpedia.org%2Fresource%2FBRCA_mutation

A BRCA mutation is a mutation in either of the BRCA1 and BRCA2 genes, which are tumour suppressor genes. Hundreds of different types of mutations in these genes have been identified, some of which have been determined to be harmful, while others have no proven impact. Harmful mutations in these genes may produce a hereditary breast–ovarian cancer syndrome in affected persons. Only 5–10% of breast cancer cases in women are attributed to BRCA1 and BRCA2 mutations (with BRCA1 mutations being slightly more common than BRCA2 mutations), but the impact on women with the gene mutation is more profound. Women with harmful mutations in either BRCA1 or BRCA2 have a risk of breast cancer that is about five times the normal risk, and a risk of ovarian cancer that is about ten to thirty times normal. T

Attributes	Values
rdf:type	Thing Fuchs' dystrophy yago:Abstraction100002137 yago:Attribute100024264 yago:Cancer114239918 yago:Condition113920835 yago:Disease114070360 yago:Growth114234074 yago:IllHealth114052046 yago:Illness114061805 yago:Malignancy114237561 yago:MalignantTumor114239425 yago:PathologicalState114051917 yago:PhysicalCondition114034177 yago:WikicatHereditaryCancers disease bird yago:State100024720 yago:Tumor114235200
rdfs:label	BRCA mutation (en) طفرة BRCA (ar) Μετάλλαξη BRCA (el) Mutação BRCA (pt)
rdfs:comment	Uma mutação BRCA é qualquer mutação genética que ocorra nos genes supressores de tumores BRCA1 ou BRCA2. Estão identificados centenas de diferentes tipos de mutações, sendo muitas inofensivas enquanto outras são nocivas. As mutações nocivas nestes genes podem aumentar o risco de desenvolver vários tipos de cancro, sobretudo cancro da mama e cancro do ovário. (pt) طفرة BRCA هي طفرة في أيا من جينات و BRCA2، وهي جينات قامعة للورم. تم تحديد مئات الأنواع المختلفة من الطفرات في هذه الجينات، البعض منها قد ثبت أنه ضار، في حين أن البعض الآخر ليس له تأثير مثبت. قد تحدث طفرات ضارة في هذه الجينات متلازمة سرطان الثدي المبيض الوراثي في الأشخاص المتضررين. تُعزى فقط 5-10٪ من حالات سرطان الثدي لدى النساء إلى طفرات BRCA1 و BRCA2 (مع ان طفرات BRCA1 أكثر شيوعًا بشكل طفيف من طفرات BRCA2) ، ولكن التأثير على (ar) Ως μετάλλαξη BRCA ορίζεται η μετάλλαξη που προκαλείται σε κάποιο από τα γονίδια BRCA1 και BRCA2. Οι παθολογικές μεταλλάξεις σε αυτά τα γονίδια προκαλούν το σύνδρομο του κληρονομικού καρκίνου του μαστού και των ωοθηκών. Αν και ο καρκίνος του μαστού είναι σχετικά κοινός, οι μεταλλάξεις στα BRCA1 και BRCA2 είναι σπάνιες, επομένως οι μεταλλάξεις αυτές είναι υπεύθυνες για το μόλις 5 έως 10% των περιπτώσεων καρκίνου του μαστού στις γυναίκες. (el) A BRCA mutation is a mutation in either of the BRCA1 and BRCA2 genes, which are tumour suppressor genes. Hundreds of different types of mutations in these genes have been identified, some of which have been determined to be harmful, while others have no proven impact. Harmful mutations in these genes may produce a hereditary breast–ovarian cancer syndrome in affected persons. Only 5–10% of breast cancer cases in women are attributed to BRCA1 and BRCA2 mutations (with BRCA1 mutations being slightly more common than BRCA2 mutations), but the impact on women with the gene mutation is more profound. Women with harmful mutations in either BRCA1 or BRCA2 have a risk of breast cancer that is about five times the normal risk, and a risk of ovarian cancer that is about ten to thirty times normal. T (en)
foaf:name	BRCA mutation (en)
name	BRCA mutation (en)
foaf:depiction
dcterms:subject	Breast cancer Hereditary cancers Ovarian cancer Mutation
Wikipage page ID	26799151 (xsd:integer)
Wikipage revision ID	1107586563 (xsd:integer)
Link from a Wikipage to another Wikipage	Cataract Scintimammography Elastography FANCD2 Mutation Melanocytic nevus Menarche Meta-analysis Biopsies Breast MRI Breast cancer Allele Uveal melanoma Indication (medicine) Informed consent Inframammary fold Invasive (medical) Penetrance Mastectomy Melanoma Salpingectomy Salpingo-oophorectomy Genetic counseling Chronic lymphocytic leukemia Chronic myelogenous leukemia Cisplatin Endometrial cancer Gene Genetic carrier Myriad Genetics T-cell lymphoma Aromatase inhibitor Mammogram Mammograms Ashkenazi Jewish Statistical significance Hot flash Birth control pill Pancreatic cancer Primary ovarian insufficiency Progesterone receptor Prostate cancer Patentable subject matter Sterility (physiology) Symptom Tattoo Triple-negative breast cancer Tumor suppressor gene Medical genetics Hormone replacement therapy (menopause) Breast cancer CA-125 CT scan Cervicectomy Trastuzumab Ductal lavage Colon (anatomy) Adipose tissue Estrogen receptor Fanconi anemia Fertility Breast cancer screening

Faceted Search & Find service v1.17_git139 as of Feb 29 2024

Alternative Linked Data Documents: ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 08.03.3330 as of Mar 19 2024, on Linux (x86_64-generic-linux-glibc212), Single-Server Edition (61 GB total memory, 51 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software