Anna Diogenissa (Greek: Ἄννα Διογένισσα; ca. 1074–1145) was a Byzantine noblewoman of the Diogenes house who became the Grand Princess consort of Serbia as wife of Uroš I Vukanović (r. 1112–1145). She had five children with Uroš I, including the successor, Uroš II (r. 1145–1162).