The 2022 North Dakota State Bison softball team was an American college softball team that represented North Dakota State University during the 2022 NCAA Division I softball season. The Bison were led by Darren Mueller in his twenty-first season, and played their home games at . They competed in the Summit League. The Bison finished the season with a 30-23 record, and a 10-8 record in Summit League play. NDSU made it to the Summit League Tournament as the 3 seed. They defeated North Dakota and Omaha, before falling to South Dakota State and Omaha in the elimination game to be eliminated from contention.